METTL1

Across TCGA patient cohorts, METTL1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL1-associated genes across cancer lineages are FOXO3a, Tuberin, and eIF4E. Each is linked with METTL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL1-to-partner and partner-to-METTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by METTL1-low versus METTL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL1→partner) and Y-score (partner→METTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	+0.148	+3.013	.011	.019	3	1
UCEC	Tuberin →	+0.480	+2.817	.002	.036	3	1
UCEC	eIF4E →	+0.266	+3.000	.029	.037	2	1
UCEC	Caspase-8 →	-0.343	-3.000	.018	.037	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

FOXO3a by METTL1 expression — UCEC

Explore this box plot interactively →