METTL1

Across TCGA cell cohorts, METTL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,076 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible METTL1-associated GO terms across cancer lineages are Regulation of tRNA catabolic process, Negative regulation of tRNA catabolic process, and Regulation of tRNA stability. Each is linked with METTL1 in more than 19 cancer types. Because this analysis shows association rather than direction, both METTL1-to-partner and partner-to-METTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of tRNA catabolic process grouped by METTL1-low versus METTL1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL1→partner) and Y-score (partner→METTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of tRNA catabolic process →	+0.189	+1.801	<.001	<.001	3	20
SOFT_TISSUE	Negative regulation of tRNA catabolic process →	+0.189	+1.801	<.001	<.001	3	20
SOFT_TISSUE	Regulation of tRNA stability →	+0.189	+1.801	<.001	<.001	3	20
SOFT_TISSUE	tRNA stabilization →	+0.189	+1.801	<.001	<.001	3	20
BONE	Regulation of tRNA metabolic process →	+0.173	+1.642	<.001	.001	3	17
LIVER	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.224	+1.171	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,076 associations by consensus.

Regulation of tRNA catabolic process by METTL1 expression — SOFT_TISSUE

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