METRNL

Across TCGA patient cohorts, METRNL mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METRNL-associated genes across cancer lineages are ERK2, Fibronectin, and JNK2. Each is linked with METRNL in more than 1 cancer types. Because this analysis shows association rather than direction, both METRNL-to-partner and partner-to-METRNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by METRNL-low versus METRNL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METRNL→partner) and Y-score (partner→METRNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.202	+3.000	.030	.036	3	1
UCEC	Fibronectin →	-0.425	-2.459	.007	.020	3	1
UCEC	JNK2 →	+0.323	+3.584	<.001	.002	3	1
UCEC	TAZ →	-0.143	-2.990	.036	.036	3	1
UCEC	ATM →	-0.542	-3.584	.013	.002	3	1
UCEC	Caspase-8 →	-0.249	-3.169	.040	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ERK2 by METRNL expression — UCEC

Explore this box plot interactively →