METRNL

Across TCGA cell cohorts, METRNL RNA expression is significantly associated with the go_rna of many other GO terms, with 5,262 significant associations in total. BONE shows the largest number of these associations.

The most reproducible METRNL-associated GO terms across cancer lineages are Brown fat cell differentiation, Regulation of proteolysis, and Protein localization to endoplasmic reticulum. Each is linked with METRNL in more than 14 cancer types. Because this analysis shows association rather than direction, both METRNL-to-partner and partner-to-METRNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Brown fat cell differentiation grouped by METRNL-low versus METRNL-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METRNL→partner) and Y-score (partner→METRNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Brown fat cell differentiation →	+0.252	+1.905	<.001	<.001	3	15
BONE	Regulation of proteolysis →	+0.121	+2.881	<.001	<.001	3	12
SOFT_TISSUE	Protein localization to endoplasmic reticulum →	+0.120	+2.024	<.001	<.001	3	12
PANCREAS	Response to unfolded protein →	+0.068	+1.094	<.001	<.001	3	10
LIVER	Regulation of calcineurin-NFAT signaling cascade →	+0.178	+2.423	.001	.001	2	11
BONE	Actomyosin contractile ring assembly actin filament organization →	+0.284	+2.525	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,262 associations by consensus.

Brown fat cell differentiation by METRNL expression — OESOPHAGUS

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