METRNL

Across TCGA cell cohorts, METRNL mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. CNS shows the largest number of these associations.

The most reproducible METRNL-associated genes across cancer lineages are BIRC8, FOXB2, and USP17L17. Each is linked with METRNL in more than 1 cancer types. Because this analysis shows association rather than direction, both METRNL-to-partner and partner-to-METRNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BIRC8 grouped by METRNL-low versus METRNL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METRNL→partner) and Y-score (partner→METRNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BIRC8 →	+0.012	+4.977	<.001	.007	3	1
STOMACH	FOXB2 →	+0.013	+5.285	<.001	.003	3	1
STOMACH	USP17L17 →	+0.013	+5.285	<.001	.003	3	1
CNS	DEFA6 →	+0.081	+4.981	<.001	.008	3	1
CNS	OR5AK2 →	+0.022	+5.321	<.001	.005	3	1
CNS	URAD →	+0.019	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

BIRC8 by METRNL expression — SKIN

Explore this box plot interactively →