METAP2

Across TCGA patient cohorts, METAP2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METAP2-associated genes across cancer lineages are Shc_pY317, FoxM1, and mTOR_pS2448. Each is linked with METAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both METAP2-to-partner and partner-to-METAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by METAP2-low versus METAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METAP2→partner) and Y-score (partner→METAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.141	-2.584	.015	.010	3	2
UCEC	FoxM1 →	+0.223	+1.678	.024	.023	3	1
UCEC	mTOR_pS2448 →	-0.141	-2.565	.013	.010	3	1
UCEC	Notch1 →	+0.154	+2.710	.004	.003	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.394	-1.807	.022	.025	3	1
UCEC	PDCD4 →	-0.519	-3.169	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Shc_pY317 by METAP2 expression — UCEC

Explore this box plot interactively →