METAP2

Across TCGA cell cohorts, METAP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,995 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible METAP2-associated GO terms across cancer lineages are rRNA 5'-end processing, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and DNA-templated DNA replication. Each is linked with METAP2 in more than 17 cancer types. Because this analysis shows association rather than direction, both METAP2-to-partner and partner-to-METAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA 5'-end processing grouped by METAP2-low versus METAP2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METAP2→partner) and Y-score (partner→METAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	rRNA 5'-end processing →	+0.179	+0.766	.001	.004	3	18
LIVER	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.179	+0.766	.001	.004	3	18
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.158	+1.144	<.001	<.001	3	17
LIVER	Maturation of SSU-rRNA →	+0.162	+1.064	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.198	+1.163	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.166	+1.006	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,995 associations by consensus.

rRNA 5'-end processing by METAP2 expression — LIVER

Explore this box plot interactively →