METAP2

Across TCGA cell cohorts, METAP2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible METAP2-associated genes across cancer lineages are PRDM14, MYH6, and MLN. Each is linked with METAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both METAP2-to-partner and partner-to-METAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDM14 grouped by METAP2-low versus METAP2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METAP2→partner) and Y-score (partner→METAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PRDM14 →	+1.167	+4.135	<.001	.007	3	1
OVARY	MYH6 →	+0.053	+3.938	<.001	.005	3	1
OVARY	MLN →	+0.534	+4.222	<.001	.006	3	1
LARGE_INTESTINE	CHRNA2 →	+0.100	+3.453	<.001	.009	3	1
LARGE_INTESTINE	TTLL8 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PRDM14 by METAP2 expression — OVARY

Explore this box plot interactively →