METAP1

Across TCGA pan-cancer cohorts, METAP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated METAP1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher METAP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated METAP1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where METAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.933	0.730	.001	33	view →
HNSC	DFS	Median	III,IV	0.777	0.520	.007	20	view →
PDAC	DFS	Median	II,III,IV	0.312	0.462	.009	19	view →
UCEC	DFS	Tertile	All	1.000	0.762	.001	16	view →
LSCC	DFS	Median	All	1.000	0.867	.002	12	view →
GBM	OS	Median	All	0.744	0.882	.018	4	view →
LUAD	OS	Median	All	0.999	0.923	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

METAP1–CCRCC (OS)

Open the CCRCC breakdown →