METAP1

Across TCGA patient cohorts, METAP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,706 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible METAP1-associated proteins across cancer lineages are POLDIP3, MORC2, and WIZ. Each is linked with METAP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both METAP1-to-partner and partner-to-METAP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, METAP1 versus POLDIP3 in BRCA, with a Pearson correlation of 0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (METAP1→partner) and Y-score (partner→METAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POLDIP3 →	+0.252	+0.322	.005	.007	3	5
BRCA	MORC2 →	+0.467	+0.333	<.001	.002	3	5
GBM	WIZ →	+0.431	+0.286	<.001	<.001	3	5
UCEC	ARHGEF6_S225 →	-0.537	-0.528	<.001	<.001	3	5
BRCA	ANKRD17 →	+0.345	+0.508	<.001	<.001	3	5
BRCA	EIF4E →	+0.268	+0.420	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,706 associations by consensus.

METAP1 vs POLDIP3 — BRCA

Explore this scatter interactively →