METAP1

Across TCGA patient cohorts, METAP1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,715 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible METAP1-associated genes across cancer lineages are ASPA, RASGRP4, and ZCCHC24. Each is linked with METAP1 in more than 6 cancer types. Because this analysis shows association rather than direction, both METAP1-to-partner and partner-to-METAP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, METAP1 versus ASPA in GBM, with a Pearson correlation of -0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METAP1→partner) and Y-score (partner→METAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ASPA →	-0.656	-0.116	.004	.006	3	7
BRCA	RASGRP4 →	-0.469	-0.252	<.001	.001	3	7
OV	ZCCHC24 →	-0.907	-0.265	.001	.006	3	6
HNSC	ELMO1 →	-0.691	-0.207	<.001	<.001	3	6
UCEC	ENOPH1 →	+0.456	+0.169	.005	.002	3	5
LSCC	CFH →	-1.122	-0.286	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,715 associations by consensus.

METAP1 vs ASPA — GBM

Explore this scatter interactively →