METAP1

Across TCGA patient cohorts, METAP1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METAP1-associated genes across cancer lineages are p62 Lck ligand, C-Raf, and A-Raf_pS299. Each is linked with METAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both METAP1-to-partner and partner-to-METAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by METAP1-low versus METAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METAP1→partner) and Y-score (partner→METAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.332	+2.807	.002	.002	3	2
UCEC	C-Raf →	+0.140	+1.502	.003	.027	3	2
UCEC	A-Raf_pS299 →	-0.159	-2.087	<.001	.005	3	1
UCEC	ERK2 →	+0.243	+1.874	<.001	.002	3	1
UCEC	Heregulin →	-0.147	-2.209	<.001	.009	3	1
UCEC	IGFBP2 →	-0.611	-2.000	.004	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

p62 Lck ligand by METAP1 expression — UCEC

Explore this box plot interactively →