METAP1

Across TCGA cell cohorts, METAP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,954 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible METAP1-associated GO terms across cancer lineages are Mitotic nuclear division, Meiotic chromosome condensation, and Protein localization to condensed chromosome. Each is linked with METAP1 in more than 13 cancer types. Because this analysis shows association rather than direction, both METAP1-to-partner and partner-to-METAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic nuclear division grouped by METAP1-low versus METAP1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METAP1→partner) and Y-score (partner→METAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Mitotic nuclear division →	+0.088	+0.674	.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Meiotic chromosome condensation →	+0.144	+0.714	<.001	<.001	3	13
SOFT_TISSUE	Protein localization to condensed chromosome →	+0.125	+0.738	<.001	<.001	3	13
SOFT_TISSUE	Replication fork processing →	+0.108	+0.740	<.001	<.001	3	13
LARGE_INTESTINE	Nuclear pore complex assembly →	+0.137	+0.908	<.001	<.001	3	13
BONE	Sister chromatid segregation →	+0.083	+0.506	.005	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,954 associations by consensus.

Mitotic nuclear division by METAP1 expression — SOFT_TISSUE

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