MEST

Across TCGA pan-cancer cohorts, MEST mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MEST data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MEST mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MEST expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

UCEC, LSCC, and CCRCC are the cancer types where MEST mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.895	1.000	.005	20	view →
LSCC	DFS	Quartile	III,IV	0.378	0.902	.001	10	view →
CCRCC	OS	Median	All	1.000	0.802	.004	7	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
OV	DFS	Median	All	0.854	1.000	.031	4	view →
LUAD	OS	Quartile	II,III,IV	0.404	0.729	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MEST–UCEC (OS)

Open the UCEC breakdown →