MEST

Across TCGA patient cohorts, MEST mutation is significantly associated with the RNA expression of many other genes, with 1,426 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEST-associated genes across cancer lineages are SNRPEP7, RARRES2P5, and TNPO3P1. Each is linked with MEST in more than 2 cancer types. Because this analysis shows association rather than direction, both MEST-to-partner and partner-to-MEST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPEP7 grouped by MEST-low versus MEST-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEST→partner) and Y-score (partner→MEST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SNRPEP7 →	+0.221	+4.875	<.001	.002	3	3
SKCM	RARRES2P5 →	+0.153	+2.915	<.001	.008	3	2
LUSC	TNPO3P1 →	+0.064	+5.548	.002	.004	3	2
UCEC	GUF1 →	+0.443	+3.364	.003	.004	3	2
UCEC	TATDN2 →	+0.308	+2.343	.009	.003	3	2
UCEC	SYNJ1 →	+0.383	+2.354	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,426 associations by consensus.

SNRPEP7 by MEST expression — BRCA

Explore this box plot interactively →