MEST

Across TCGA patient cohorts, MEST mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEST-associated genes across cancer lineages are mTOR_pS2448, VHL, and eIF4E. Each is linked with MEST in more than 1 cancer types. Because this analysis shows association rather than direction, both MEST-to-partner and partner-to-MEST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by MEST-low versus MEST-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEST→partner) and Y-score (partner→MEST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.226	-3.302	.001	.010	3	2
UCEC	VHL →	-1.086	-3.321	<.001	.010	3	2
UCEC	eIF4E →	+0.214	+3.013	.036	.018	3	1
UCEC	Ku80 →	+0.228	+2.817	.045	.036	3	1
UCEC	MEK1 →	+0.460	+3.584	.009	.002	3	1
UCEC	Notch1 →	+0.230	+2.459	<.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

mTOR_pS2448 by MEST expression — UCEC

Explore this box plot interactively →