MEST

Across TCGA cell cohorts, MEST RNA expression is significantly associated with the go_rna of many other GO terms, with 4,006 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MEST-associated GO terms across cancer lineages are Radial glia-guided pyramidal neuron migration, Stress granule assembly, and Spliceosomal snRNP assembly. Each is linked with MEST in more than 15 cancer types. Because this analysis shows association rather than direction, both MEST-to-partner and partner-to-MEST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Radial glia-guided pyramidal neuron migration grouped by MEST-low versus MEST-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MEST→partner) and Y-score (partner→MEST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Radial glia-guided pyramidal neuron migration →	+0.938	+4.720	<.001	<.001	3	16
BLOOD_Leukemia	Stress granule assembly →	+0.051	+2.061	.009	.002	3	9
OESOPHAGUS	Spliceosomal snRNP assembly →	+0.095	+2.217	<.001	.008	2	9
BLOOD_Leukemia	Positive regulation of translation →	+0.032	+1.702	<.001	<.001	3	8
KIDNEY	Vesicle budding from membrane →	+0.064	+2.391	.002	.007	3	8
SKIN	RNA methylation →	+0.053	+2.387	.001	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,006 associations by consensus.

Radial glia-guided pyramidal neuron migration by MEST expression — LUNG_SCLC

Explore this box plot interactively →