Across TCGA patient cohorts, MESP2 mutation is significantly associated with the RNA expression of many other genes, with 520 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MESP2-associated genes across cancer lineages are RNU6-633P, RN7SKP3, and TCEAL4P1. Each is linked with MESP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MESP2-to-partner and partner-to-MESP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MESP2→partner) and Y-score (partner→MESP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-633P →	+0.333	+4.867	<.001	.005	3	2
LUSC	RN7SKP3 →	+0.112	+5.578	<.001	.002	3	2
LUSC	TCEAL4P1 →	+0.065	+5.309	.009	.003	3	2
LUSC	LINC01848 →	+0.447	+4.447	<.001	.006	3	2
LUSC	RNA5SP536 →	+0.228	+4.978	<.001	.005	3	2
UCEC	CWC25 →	+0.472	+3.337	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 520 associations by consensus.

Exploration

MESP2 survival (RNA) · tumor vs normal (RNA) · all MESP2 data types