Across TCGA patient cohorts, MESP2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MESP2-associated genes across cancer lineages are Heregulin, MEK1, and P-Cadherin. Each is linked with MESP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MESP2-to-partner and partner-to-MESP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MESP2→partner) and Y-score (partner→MESP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.176	-3.000	.006	.036	3	1
UCEC	MEK1 →	+0.631	+3.321	<.001	.010	3	1
UCEC	P-Cadherin →	-0.199	-2.990	.008	.036	3	1
UCEC	Rictor_pT1135 →	-0.141	-2.999	.008	.035	3	1
UCEC	VEGFR2 →	+0.324	+2.183	.037	.035	3	1
UCEC	ATM →	-0.654	-2.986	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

MESP2 survival (RNA) · tumor vs normal (RNA) · all MESP2 data types