MESD

Across TCGA cell cohorts, MESD RNA expression is significantly associated with the go_rna of many other GO terms, with 4,197 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MESD-associated GO terms across cancer lineages are Protein N-linked glycosylation, Multi-pass transmembrane protein insertion into ER membrane, and Regulation of translational initiation in response to stress. Each is linked with MESD in more than 14 cancer types. Because this analysis shows association rather than direction, both MESD-to-partner and partner-to-MESD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein N-linked glycosylation grouped by MESD-low versus MESD-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MESD→partner) and Y-score (partner→MESD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Protein N-linked glycosylation →	+0.083	+0.638	.004	.006	2	15
LIVER	Multi-pass transmembrane protein insertion into ER membrane →	+0.159	+0.707	.001	.003	3	12
URINARY_TRACT	Regulation of translational initiation in response to stress →	+0.165	+0.756	<.001	.002	3	12
BONE	Glycoprotein biosynthetic process →	+0.055	+0.546	<.001	.001	3	12
LIVER	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.146	+0.721	<.001	<.001	3	11
BLOOD_Lymphoma	Endoplasmic reticulum to cytosol transport →	+0.133	+0.840	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,197 associations by consensus.

Protein N-linked glycosylation by MESD expression — LIVER

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