MESD

Across TCGA cell cohorts, MESD mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MESD-associated genes across cancer lineages are MDGA2, FANCD2OS, and UCMA. Each is linked with MESD in more than 1 cancer types. Because this analysis shows association rather than direction, both MESD-to-partner and partner-to-MESD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDGA2 grouped by MESD-low versus MESD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MESD→partner) and Y-score (partner→MESD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MDGA2 →	+0.148	+3.176	<.001	.003	3	1
LARGE_INTESTINE	FANCD2OS →	+0.111	+3.362	.004	.007	3	1
LARGE_INTESTINE	UCMA →	+0.015	+3.217	<.001	.006	3	1
LARGE_INTESTINE	WDR87 →	+0.024	+3.716	<.001	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+3.562	<.001	.002	3	1
LARGE_INTESTINE	IFNA1 →	+0.648	+2.994	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MDGA2 by MESD expression — LARGE_INTESTINE

Explore this box plot interactively →