MERTK

Across TCGA pan-cancer cohorts, MERTK mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MERTK’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where MERTK mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MERTK is over-expressed in tumor, although a few such as PDAC and LUAD show the opposite, repressed pattern.

PDAC, LUAD, and CCRCC are the cancer types where MERTK tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MERTK mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	−0.283	.037	2	view →
LUAD	All	All	−0.116	.001	2	view →
CCRCC	Female	All	+0.326	.046	1	view →
LSCC	All	All	+0.118	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MERTK–PDAC

Open the PDAC breakdown →