MERTK

Across TCGA patient cohorts, MERTK mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MERTK-associated genes across cancer lineages are HER3_pY1289, Caspase-8, and JNK2. Each is linked with MERTK in more than 1 cancer types. Because this analysis shows association rather than direction, both MERTK-to-partner and partner-to-MERTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by MERTK-low versus MERTK-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MERTK→partner) and Y-score (partner→MERTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	HER3_pY1289 →	+0.107	+2.816	.036	.036	3	2
UCEC	Caspase-8 →	-0.263	-3.880	.004	<.001	3	2
UCEC	JNK2 →	+0.273	+2.736	<.001	<.001	3	2
UCEC	Rictor_pT1135 →	-0.103	-3.459	.006	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.630	+1.502	.003	.030	3	2
COAD	Snail →	+0.788	+2.178	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

HER3_pY1289 by MERTK expression — LUSC

Explore this box plot interactively →