MERTK

Across TCGA cell cohorts, MERTK RNA expression is significantly associated with the go_rna of many other GO terms, with 4,107 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MERTK-associated GO terms across cancer lineages are Granzyme-mediated apoptotic signaling pathway, Extracellular matrix organization, and Extracellular structure organization. Each is linked with MERTK in more than 8 cancer types. Because this analysis shows association rather than direction, both MERTK-to-partner and partner-to-MERTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Granzyme-mediated apoptotic signaling pathway grouped by MERTK-low versus MERTK-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MERTK→partner) and Y-score (partner→MERTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Granzyme-mediated apoptotic signaling pathway →	+0.095	+1.403	.001	.007	3	9
BONE	Extracellular matrix organization →	-0.289	-2.202	<.001	<.001	3	8
BONE	Extracellular structure organization →	-0.291	-2.202	<.001	<.001	3	8
BONE	External encapsulating structure organization →	-0.288	-2.202	<.001	<.001	3	8
BLOOD_Leukemia	Positive regulation of telomere maintenance via telomere lengthening →	+0.058	+1.228	<.001	<.001	3	8
BLOOD_Lymphoma	Regulation of telomerase RNA localization to Cajal body →	+0.079	+0.888	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,107 associations by consensus.

Granzyme-mediated apoptotic signaling pathway by MERTK expression — BONE

Explore this box plot interactively →