MERTK

Across TCGA cell cohorts, MERTK mutation is significantly associated with the RNA expression of many other genes, with 802 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MERTK-associated genes across cancer lineages are H2BC1, H2AC1, and FIGLA. Each is linked with MERTK in more than 1 cancer types. Because this analysis shows association rather than direction, both MERTK-to-partner and partner-to-MERTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC1 grouped by MERTK-low versus MERTK-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MERTK→partner) and Y-score (partner→MERTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BC1 →	+0.325	+4.977	<.001	.002	3	1
SOFT_TISSUE	H2AC1 →	+0.145	+4.977	<.001	.002	3	1
SOFT_TISSUE	FIGLA →	+0.082	+4.222	.003	.007	3	1
SOFT_TISSUE	KRTAP10-1 →	+0.062	+5.954	<.001	<.001	3	1
OESOPHAGUS	BANF2 →	+0.146	+4.906	<.001	.006	3	1
OESOPHAGUS	MS4A6E →	+0.050	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 802 associations by consensus.

H2BC1 by MERTK expression — SOFT_TISSUE

Explore this box plot interactively →