MERTK

Across TCGA cell cohorts, MERTK mutation is significantly associated with the mutation status of many other genes, with 5,187 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MERTK-associated genes across cancer lineages are NLRP7, TP53BP1, and COL4A4. Each is linked with MERTK in more than 3 cancer types. Because this analysis shows association rather than direction, both MERTK-to-partner and partner-to-MERTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP7 grouped by MERTK-low versus MERTK-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MERTK→partner) and Y-score (partner→MERTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NLRP7 →	+5.000	+4.044	.008	.008	1	4
LARGE_INTESTINE	TP53BP1 →	+2.182	+2.485	<.001	<.001	1	4
SOFT_TISSUE	COL4A4 →	+3.722	+4.022	.003	.003	1	3
LARGE_INTESTINE	SEMA5B →	+1.959	+1.959	.009	.009	1	3
LARGE_INTESTINE	SPAG9 →	+2.404	+2.404	.001	.001	1	3
SOFT_TISSUE	TRPM3 →	+4.722	+5.437	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,187 associations by consensus.

NLRP7 by MERTK expression — CNS

Explore this box plot interactively →