MEP1B

Across TCGA pan-cancer cohorts, MEP1B RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MEP1B data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MEP1B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MEP1B expression acts as an unfavorable survival marker, although some lineages such as GBM and SCLC show a favorable association.

ACC, THCA, and GBM are the cancer types where MEP1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.690	0.931	<.001	109	view →
THCA	OS	Median	IV	0.555	0.939	.001	54	view →
GBM	DFS	Tertile	All	0.319	0.154	<.001	36	view →
CHOL	DFS	Quartile	II,III,IV	0.131	0.417	.003	21	view →
SCLC	DFS	Tertile	All	0.403	0.121	.017	16	view →
LIHC	OS	Quartile	All	0.833	0.508	.002	16	view →
READ	OS	Median	IV	0.510	0.855	.014	10	view →
PRAD	OS	Quartile	All	0.961	0.995	.023	10	view →
KICH	DFS	Quartile	II,III,IV	0.415	0.835	.018	9	view →
THYM	OS	Quartile	II,III,IV	0.601	0.964	.034	5	view →
BLCA	DFS	Median	III,IV	0.466	0.281	.034	5	view →
OV	OS	Quartile	IV	0.529	0.258	.041	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MEP1B–ACC (OS)

Open the ACC breakdown →