MEP1A

Across TCGA patient cohorts, MEP1A mutation is significantly associated with the RNA expression of many other genes, with 3,908 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEP1A-associated genes across cancer lineages are MIR4804, SCLT1, and MARCHF2. Each is linked with MEP1A in more than 3 cancer types. Because this analysis shows association rather than direction, both MEP1A-to-partner and partner-to-MEP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4804 grouped by MEP1A-low versus MEP1A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEP1A→partner) and Y-score (partner→MEP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR4804 →	+0.733	+3.415	<.001	.002	3	4
UCEC	SCLT1 →	+0.299	+2.254	.007	.005	3	3
UCEC	MARCHF2 →	+0.285	+2.210	.005	.001	3	3
UCEC	RNU6-1082P →	+0.118	+2.118	.005	.006	3	3
SKCM	NOL7 →	+0.391	+2.688	<.001	<.001	3	3
UCEC	NEK4 →	+0.465	+2.136	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,908 associations by consensus.

MIR4804 by MEP1A expression — LUAD

Explore this box plot interactively →