MEP1A

Across TCGA patient cohorts, MEP1A mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEP1A-associated genes across cancer lineages are VHL, HER2, and MYH11. Each is linked with MEP1A in more than 2 cancer types. Because this analysis shows association rather than direction, both MEP1A-to-partner and partner-to-MEP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by MEP1A-low versus MEP1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEP1A→partner) and Y-score (partner→MEP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.621	-1.678	.008	.021	3	3
SKCM	HER2 →	+0.286	+1.919	.005	.008	3	2
SKCM	MYH11 →	-0.682	-2.087	.030	.004	3	2
SKCM	Rictor_pT1135 →	+0.122	+1.519	.030	.017	3	2
UCEC	EGFR_pY1068 →	-0.257	-1.736	.003	.007	3	2
UCEC	mTOR_pS2448 →	-0.116	-2.209	.024	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

VHL by MEP1A expression — UCEC

Explore this box plot interactively →