MEP1A

Across TCGA cell cohorts, MEP1A mutation is significantly associated with the RNA expression of many other genes, with 108 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEP1A-associated genes across cancer lineages are SHCBP1L, HHLA1, and ASZ1. Each is linked with MEP1A in more than 1 cancer types. Because this analysis shows association rather than direction, both MEP1A-to-partner and partner-to-MEP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHCBP1L grouped by MEP1A-low versus MEP1A-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEP1A→partner) and Y-score (partner→MEP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SHCBP1L →	+0.086	+4.906	<.001	.006	3	1
BLOOD_Leukemia	HHLA1 →	+0.011	+4.551	<.001	.004	3	1
BLOOD_Leukemia	ASZ1 →	+0.119	+4.152	.001	.009	3	1
BLOOD_Leukemia	CNGA2 →	+0.074	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CCT8L2 →	+0.011	+4.874	<.001	.002	3	1
BLOOD_Leukemia	TSSK1B →	+0.019	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 108 associations by consensus.

SHCBP1L by MEP1A expression — OESOPHAGUS

Explore this box plot interactively →