MEOX1

Across TCGA patient cohorts, MEOX1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEOX1-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and Notch1. Each is linked with MEOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEOX1-to-partner and partner-to-MEOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MEOX1-low versus MEOX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEOX1→partner) and Y-score (partner→MEOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.204	+3.169	<.001	.020	3	2
UCEC	ERK2 →	+0.265	+3.169	.012	.020	3	1
UCEC	Notch1 →	+0.185	+3.009	.016	.019	3	1
UCEC	Akt_pS473 →	-0.941	-3.169	.016	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.667	-3.000	.006	.036	3	1
UCEC	4E-BP1_pT37_T46 →	-0.599	-2.986	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Caspase-7-cleavedD198 by MEOX1 expression — UCEC

Explore this box plot interactively →