MEN1

Across TCGA pan-cancer cohorts, MEN1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MEN1 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MEN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MEN1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where MEN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.711	1.000	.004	21	view →
LSCC	OS	Median	All	0.885	0.751	.019	11	view →
LUAD	DFS	Quartile	All	0.798	0.279	.011	10	view →
GBM	DFS	Median	All	0.335	0.201	.010	9	view →
PDAC	DFS	Tertile	IV	0.934	0.228	.024	6	view →
CCRCC	DFS	Median	II,III,IV	0.721	0.490	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MEN1–HNSC (DFS)

Open the HNSC breakdown →