MEN1

Across TCGA patient cohorts, MEN1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEN1-associated genes across cancer lineages are Caspase-7-cleavedD198, PI3K-p85, and EGFR_pY1068. Each is linked with MEN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MEN1-to-partner and partner-to-MEN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MEN1-low versus MEN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEN1→partner) and Y-score (partner→MEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.519	+3.189	.029	.010	3	3
UCEC	PI3K-p85 →	+0.169	+3.169	.044	.018	3	2
UCEC	EGFR_pY1068 →	-0.230	-2.415	.022	.003	3	1
UCEC	eIF4E →	+0.179	+2.459	.035	.019	3	1
UCEC	ERK2 →	+0.216	+2.415	.005	.003	3	1
UCEC	Heregulin →	-0.123	-2.000	.013	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Caspase-7-cleavedD198 by MEN1 expression — UCEC

Explore this box plot interactively →