MELTF

Across TCGA pan-cancer cohorts, MELTF mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of MELTF’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where MELTF mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MELTF is over-expressed in tumor, although a few such as OV show the opposite, repressed pattern.

PDAC, LSCC, and COAD are the cancer types where MELTF tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MELTF mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	+0.855	<.001	10	view →
LSCC	Male	III,IV	+1.098	<.001	8	view →
COAD	Female	All	+0.482	.012	6	view →
CCRCC	Female	All	+0.692	.018	4	view →
HNSC	All	IV	+0.378	.016	4	view →
OV	All	All	−0.820	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

MELTF–PDAC

Open the PDAC breakdown →