MELK

Across TCGA pan-cancer cohorts, MELK mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MELK data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MELK mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MELK expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LUAD, GBM, and LSCC are the cancer types where MELK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.290	0.840	.038	4	view →
GBM	OS	Quartile	All	0.909	0.358	.024	2	view →
LSCC	OS	Quartile	All	0.897	1.000	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MELK–LUAD (OS)

Open the LUAD breakdown →