MELK

Across TCGA cell cohorts, MELK RNA expression is significantly associated with the go_rna of many other GO terms, with 4,198 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MELK-associated GO terms across cancer lineages are Regulation of mitotic sister chromatid separation, Regulation of chromosome separation, and Protein localization to kinetochore. Each is linked with MELK in more than 19 cancer types. Because this analysis shows association rather than direction, both MELK-to-partner and partner-to-MELK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic sister chromatid separation grouped by MELK-low versus MELK-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MELK→partner) and Y-score (partner→MELK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of mitotic sister chromatid separation →	+0.171	+1.129	<.001	.001	3	20
OESOPHAGUS	Regulation of chromosome separation →	+0.182	+1.159	<.001	<.001	3	20
URINARY_TRACT	Protein localization to kinetochore →	+0.170	+1.454	.001	.001	3	20
OESOPHAGUS	Regulation of nuclear division →	+0.164	+1.436	<.001	.001	3	20
OESOPHAGUS	Regulation of mitotic nuclear division →	+0.175	+1.571	<.001	<.001	3	20
OESOPHAGUS	Immunoglobulin heavy chain V-D-J recombination →	+0.313	+1.492	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,198 associations by consensus.

Regulation of mitotic sister chromatid separation by MELK expression — OESOPHAGUS

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