MELK

Across TCGA cell cohorts, MELK mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MELK-associated genes across cancer lineages are APOA4, ARGFX, and TPPP2. Each is linked with MELK in more than 1 cancer types. Because this analysis shows association rather than direction, both MELK-to-partner and partner-to-MELK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOA4 grouped by MELK-low versus MELK-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MELK→partner) and Y-score (partner→MELK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	APOA4 →	+0.046	+4.215	<.001	.002	3	2
OVARY	ARGFX →	+0.049	+5.196	<.001	.005	3	2
SOFT_TISSUE	TPPP2 →	+0.168	+4.930	<.001	.008	3	1
LUNG_NSCLC_LUAD	KRTAP4-8 →	+0.158	+3.999	<.001	.004	3	1
LUNG_NSCLC_LUAD	KRTAP1-3 →	+0.048	+4.959	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.013	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

APOA4 by MELK expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →