MELK

Across TCGA cell cohorts, MELK mutation is significantly associated with the mutation status of many other genes, with 3,004 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MELK-associated genes across cancer lineages are NUTM1, SMARCA4, and MLH3. Each is linked with MELK in more than 4 cancer types. Because this analysis shows association rather than direction, both MELK-to-partner and partner-to-MELK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUTM1 grouped by MELK-low versus MELK-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MELK→partner) and Y-score (partner→MELK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NUTM1 →	+4.014	+4.969	.008	.008	1	5
SKIN	SMARCA4 →	+2.362	+2.943	.008	.008	1	4
BLOOD_Leukemia	MLH3 →	+3.145	+3.932	.004	.004	1	4
LARGE_INTESTINE	IPO4 →	+3.392	+3.632	<.001	<.001	1	4
SKIN	KMT2D →	+1.593	+3.609	.004	.004	1	3
LUNG_NSCLC_LUAD	BNC1 →	+5.000	+4.187	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,004 associations by consensus.

NUTM1 by MELK expression — BLOOD_Lymphoma

Explore this box plot interactively →