MEIS3

Across TCGA pan-cancer cohorts, MEIS3 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated MEIS3 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher MEIS3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MEIS3 expression acts as an unfavorable survival marker.

LUSC and UCEC are the cancer types where MEIS3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	III,IV	0.213	0.689	.008	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

MEIS3–LUSC (OS)

Open the LUSC breakdown →