MEIS3

Across TCGA patient cohorts, MEIS3 mutation is significantly associated with the RNA expression of many other genes, with 1,027 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEIS3-associated genes across cancer lineages are RNA5SP509, C1orf52, and ENTR1. Each is linked with MEIS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEIS3-to-partner and partner-to-MEIS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP509 grouped by MEIS3-low versus MEIS3-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEIS3→partner) and Y-score (partner→MEIS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNA5SP509 →	+0.339	+7.977	<.001	.007	3	2
UCEC	C1orf52 →	+0.440	+2.721	.002	.003	3	2
UCEC	ENTR1 →	+0.433	+2.743	.006	.003	3	2
UCEC	TIMM22 →	+0.550	+3.691	<.001	.001	3	2
UCEC	TIMM21 →	+0.523	+3.818	.004	<.001	3	2
COAD	LINC01072 →	+0.103	+3.779	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,027 associations by consensus.

RNA5SP509 by MEIS3 expression — LGG

Explore this box plot interactively →