MEIS3

Across TCGA patient cohorts, MEIS3 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEIS3-associated genes across cancer lineages are Annexin-1, eEF2, and INPP4B. Each is linked with MEIS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEIS3-to-partner and partner-to-MEIS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by MEIS3-low versus MEIS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEIS3→partner) and Y-score (partner→MEIS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.793	+2.827	.004	.035	3	2
UCEC	eEF2 →	+0.548	+3.321	.003	.010	2	2
UCEC	INPP4B →	-0.412	-3.169	.015	.019	3	1
UCEC	mTOR_pS2448 →	-0.163	-2.986	.037	.035	3	1
UCEC	PCNA →	+0.311	+3.169	.006	.019	2	2
UCEC	PEA-15_pS116 →	+0.427	+3.000	.020	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Annexin-1 by MEIS3 expression — UCEC

Explore this box plot interactively →