MEIS3

Across TCGA cell cohorts, MEIS3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MEIS3-associated genes across cancer lineages are SYT10, MYL1, and CETN1. Each is linked with MEIS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEIS3-to-partner and partner-to-MEIS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYT10 grouped by MEIS3-low versus MEIS3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEIS3→partner) and Y-score (partner→MEIS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SYT10 →	+0.393	+4.217	<.001	.001	3	1
SKIN	MYL1 →	+0.709	+4.054	<.001	.004	3	1
SKIN	CETN1 →	+0.008	+4.437	<.001	.004	3	1
SKIN	OR2M2 →	+0.046	+4.217	<.001	.001	3	1
SKIN	IL31 →	+0.021	+4.562	<.001	<.001	3	1
SKIN	TNMD →	+0.069	+3.684	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SYT10 by MEIS3 expression — SKIN

Explore this box plot interactively →