MEIS1

Across TCGA pan-cancer cohorts, MEIS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MEIS1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MEIS1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MEIS1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

LUAD, UCEC, and CCRCC are the cancer types where MEIS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.910	1.000	.014	22	view →
UCEC	OS	Tertile	All	0.818	1.000	.003	20	view →
CCRCC	DFS	Median	IV	0.162	0.733	.017	9	view →
GBM	OS	Tertile	All	0.695	0.397	.034	2	view →
HNSC	OS	Median	All	0.579	0.752	.046	1	view →
LSCC	OS	Median	II,III,IV	1.000	0.833	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MEIS1–LUAD (OS)

Open the LUAD breakdown →