MEIS1

Across TCGA cell cohorts, MEIS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,319 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MEIS1-associated GO terms across cancer lineages are Regulation of myoblast fusion, Cytoplasmic translation, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with MEIS1 in more than 11 cancer types. Because this analysis shows association rather than direction, both MEIS1-to-partner and partner-to-MEIS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by MEIS1-low versus MEIS1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MEIS1→partner) and Y-score (partner→MEIS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of myoblast fusion →	+0.107	+1.454	<.001	<.001	3	12
OESOPHAGUS	Cytoplasmic translation →	+0.126	+0.877	<.001	.004	3	12
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.108	+1.363	<.001	<.001	3	12
OVARY	Purine nucleoside triphosphate biosynthetic process →	+0.111	+2.763	<.001	<.001	3	12
OVARY	Purine ribonucleoside triphosphate biosynthetic process →	+0.111	+2.763	<.001	<.001	3	12
STOMACH	Epigenetic regulation of gene expression →	+0.072	+1.764	.002	.007	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,319 associations by consensus.

Regulation of myoblast fusion by MEIS1 expression — LUNG_SCLC

Explore this box plot interactively →