MEI1

Across TCGA cell cohorts, MEI1 mutation is significantly associated with the RNA expression of many other genes, with 269 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEI1-associated genes across cancer lineages are GALP, UGT2B28, and GRM6. Each is linked with MEI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEI1-to-partner and partner-to-MEI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALP grouped by MEI1-low versus MEI1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEI1→partner) and Y-score (partner→MEI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GALP →	+0.008	+2.830	<.001	.004	3	2
URINARY_TRACT	UGT2B28 →	+0.045	+3.632	<.001	.001	3	1
BLOOD_Myeloma	GRM6 →	+0.006	+3.754	<.001	.002	3	1
BLOOD_Myeloma	VRTN →	+0.019	+3.285	.004	.009	3	1
BLOOD_Myeloma	C1QL2 →	+0.010	+3.754	<.001	.002	3	1
BLOOD_Myeloma	RNASE11 →	+0.050	+4.700	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 269 associations by consensus.

GALP by MEI1 expression — SKIN

Explore this box plot interactively →