MEGF9

Across TCGA cell cohorts, MEGF9 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEGF9-associated genes across cancer lineages are NLRP8, SMIM28, and BTBD16. Each is linked with MEGF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEGF9-to-partner and partner-to-MEGF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP8 grouped by MEGF9-low versus MEGF9-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEGF9→partner) and Y-score (partner→MEGF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NLRP8 →	+0.026	+4.977	<.001	.007	3	1
SKIN	SMIM28 →	+0.026	+6.022	<.001	.001	3	1
BLOOD_Leukemia	BTBD16 →	+0.077	+3.959	<.001	.005	3	1
BLOOD_Leukemia	SLC35G3 →	+0.028	+3.874	.005	.005	3	1
BLOOD_Leukemia	KRT6C →	+0.021	+4.037	<.001	.004	3	1
BLOOD_Leukemia	VWC2L →	+0.012	+4.339	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

NLRP8 by MEGF9 expression — SKIN

Explore this box plot interactively →