MEGF8

Across TCGA patient cohorts, MEGF8 protein abundance is significantly associated with the RNA expression of many other genes, with 9,195 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MEGF8-associated genes across cancer lineages are CADM4, ATP7B, and DNAJC18. Each is linked with MEGF8 in more than 3 cancer types. Because this analysis shows association rather than direction, both MEGF8-to-partner and partner-to-MEGF8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MEGF8 versus CADM4 in BRCA, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEGF8→partner) and Y-score (partner→MEGF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CADM4 →	+0.841	+0.470	<.001	.001	3	4
BRCA	ATP7B →	+0.713	+0.420	.004	.001	3	4
BRCA	DNAJC18 →	+0.383	+0.382	<.001	<.001	3	4
HNSC	CLUH →	-0.743	-0.528	<.001	<.001	3	4
UCEC	LACTB →	-0.449	-0.351	.004	<.001	3	3
UCEC	KCTD9 →	-0.582	-0.384	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,195 associations by consensus.

MEGF8 vs CADM4 — BRCA

Explore this scatter interactively →