MEGF8

Across TCGA patient cohorts, MEGF8 mutation is significantly associated with the RNA expression of many other genes, with 7,862 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEGF8-associated genes across cancer lineages are COX10, SPATA5L1, and NUDT19. Each is linked with MEGF8 in more than 4 cancer types. Because this analysis shows association rather than direction, both MEGF8-to-partner and partner-to-MEGF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX10 grouped by MEGF8-low versus MEGF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEGF8→partner) and Y-score (partner→MEGF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX10 →	+0.355	+1.584	<.001	<.001	3	5
STAD	SPATA5L1 →	+0.506	+2.906	<.001	.001	3	5
STAD	NUDT19 →	+0.625	+2.923	.007	<.001	3	5
HNSC	CRYBB2P1 →	+0.482	+3.286	.006	.007	3	4
LUSC	MTND6P9 →	+0.125	+2.565	<.001	.009	3	4
LUSC	LINC01851 →	+0.423	+2.352	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,862 associations by consensus.

COX10 by MEGF8 expression — UCEC

Explore this box plot interactively →