MEGF6

Across TCGA pan-cancer cohorts, MEGF6 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MEGF6’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where MEGF6 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MEGF6 is over-expressed in tumor, although a few such as LSCC and OV show the opposite, repressed pattern.

LSCC, PDAC, and OV are the cancer types where MEGF6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MEGF6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	−0.419	<.001	7	view →
PDAC	Female	All	+0.828	<.001	6	view →
OV	All	All	−1.291	.003	2	view →
CCRCC	All	IV	+1.156	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MEGF6–LSCC

Open the LSCC breakdown →