MEGF6

Across TCGA patient cohorts, MEGF6 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEGF6-associated genes across cancer lineages are FASN, Rad50, and Caspase-7-cleavedD198. Each is linked with MEGF6 in more than 3 cancer types. Because this analysis shows association rather than direction, both MEGF6-to-partner and partner-to-MEGF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by MEGF6-low versus MEGF6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEGF6→partner) and Y-score (partner→MEGF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.492	+1.708	<.001	.026	3	4
COAD	Rad50 →	-0.264	-2.433	.004	.018	3	3
COAD	Caspase-7-cleavedD198 →	+0.953	+3.338	.001	.004	3	3
UCEC	Cyclin-B1 →	+0.492	+1.459	.006	.012	3	3
COAD	EGFR_pY1068 →	-0.328	-1.987	.008	.029	3	2
COAD	JNK_pT183_Y185 →	-0.233	-1.691	.019	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

FASN by MEGF6 expression — COAD

Explore this box plot interactively →